Focal

Causes (of multiple or abnormally-located ulcers)

Ulcer seen in histocytic lymphoma

•           Cavitary mass

•           Non-Hodgkin’s lymphoma

•           GIST (leiomyoma, leiomyosarcoma)

•           Metastatic melanoma (less commonly breast, lung)

•           Carcinoid

•           Adenocarcinoma

•           Kaposi’s sarcoma

•           Inflammatory disease

•           Crohn disease

•           Zollinger-Ellison syndrome

•           Sprue

•           Infection

•           TB – ileocecal area

•           CMV- ileal (associated with perforation)

•           Salmonella

•           Yersinia

•           Campylobacter

•           Strogyloides

•           Anisakis (roundworm)

•           Behcet’s Disease

•           Rare systemic vasculitis with ulcerations in mouth, genitalia, eyes, GI tract

•           Ileal ulcers may be aphthoid or linear

•           Radiation

•           Drug-induced

•           Potassium chloride tablets