Congenital infections such as TORCH can affect the CNS. Imaging typically demonstrates calcifications. The most common TORCH to involve the CNS is cytomegalovirus (CMV). CMV may be associated with periventricular calcifications, migrational abnormalities, cerebellar hypoplasia, and ventricular enlargement. Toxoplasmosis is the second most common. The calcifications are typically more variable in location. Imaging findings of HIV may include diffuse atrophy, delayed myelination, and calcifications most commonly in the basal ganglia and subcortical white matter of the frontal lobes.