Nearly half of all supratentorial tumors in children are glial tumors arising from the cerebral hemispheres. Symptoms of hemispheric tumors include headaches, seizures, focal neurologic deficits, and behavioral or cognitive changes. Astrocytomas are the most common source of brain neoplasms. Grading and identification of histology by imaging is not prudent based on enhancement as more rare relatively benign tumors such as pleomorphic xanthoastrocytoma (PXA) may show considerable enhancement. Astrocytomas can range from low-grade neoplasms to highly malignant glioblastoma multiforme. One third of ependymomas are supratentorial and unlike the posterior fossa ependymomas, the majority of lesions are extraventricular within brain parenchyma. Oligodendrogliomas can occur at any age but are typically tumors of young adults. Ganglioglioma, gangliocytoma, and dysembryoplastic neuroepithelial tumor (DNET) are relatively benign tumors seen in the cerebral hemispheres.