Radiobiology > Biologic Interactions > Cel Survival Curve > Curve Indices -- D0 and D1
Cell Survival Curve: Indices
From the cell survival curve, various indices are calculated.
D1 and D0 are two such entities.
- D1 is the initial slope of the survival curve
- D0 is the final slope of the curve - where the curve approximates a straight line.
D0 is also a means of representing the relative radiosensitivity of cell populations. D0 is the dose required to reduce the surviving fraction to 37% of that associated with the previous dose.
The D0 will vary according to cell type as well as the local environment in which the cell population is cultured (e.g. oxygen tension – recall oxygen increases likelihood of free radical production).
For oxygenated mammalian cells, D0 is about 150 rads (1.5 Gy).
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