Radiobiology > Biologic Interactions > Chromosomal and Chromatid Abberations
Chromosomal and Chromatid Abberations
Most chromosome aberrations lead to cell death.
Prime examples of inevitably lethal aberrations:
- Ring chromosome
- Dicentric chromosomes
- Anaphase bridge (chromatid aberration)
Prime examples of chromosomal aberrations, potentially non-lethal:
- Symmetric translocations
- Small deletions
Note that all of these radiation-induced aberrations require two double-stranded DNA breaks.
Examples of double-stranded chromosome breaks.
