Radiobiology > Biologic Interactions > Chromosomal and Chromatid Abberations

Chromosomal and Chromatid Abberations

Most chromosome aberrations lead to cell death. 

Prime examples of inevitably lethal aberrations:

  • Ring chromosome
  • Dicentric chromosomes
  • Anaphase bridge (chromatid aberration)

Prime examples of chromosomal aberrations, potentially non-lethal:

Note that all of these radiation-induced aberrations require two double-stranded DNA breaks.

Examples of double-stranded chromosome breaks.

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