Radiobiology > Deterministic Effects > Whole Body Irradiation Syndromes > Gastrointestinal Syndrome

Whole Body Irradiation: The Gastrointestinal Syndrome

The GI Syndrome

  • Associated with exposures of at least  7 to10 Gy (700 to1000 rad)
  • Mechanism: loss of stem cells from intestinal crypts, leading to eventual loss of GI mucosa
  • Si/Sx: Diarrhea and vomiting leading to profound dehydration
  • Has a latency period 3-5 days
  • Rx: Fluid resuscitation (ultimately futile)
  • Survival: None. Death in 1-2 weeks post-exposure

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